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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
《医学前沿(英文)》 2020年 第14卷 第2期 页码 136-148 doi: 10.1007/s11684-020-0756-y
关键词: human immunodeficiency virus type 1 molecular cluster transmission cluster risk network targeted intervention evaluation
Natural history of HIV infection in former plasma donors in rural China
Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU
《医学前沿(英文)》 2010年 第4卷 第3期 页码 346-350 doi: 10.1007/s11684-010-0102-x
关键词: human immunodeficiency virus (HIV) former plasma donor natural history China
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
《医学前沿(英文)》 2010年 第4卷 第3期 页码 264-270 doi: 10.1007/s11684-010-0094-6
关键词: cervical lesion high risk-human papilloma virus persistent infection loading dose cervical intraepithelial neoplasia cervical cancer
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 471-479 doi: 10.1007/s11684-017-0602-z
Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.
关键词: universal influenza virus vaccine hemagglutinin stalk H7N9
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 1-5 doi: 10.1007/s11684-014-0309-3
Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 459-462 doi: 10.1007/s11684-009-0084-8
关键词: cervical cancer human papilloma virus cervical intraepithelial neoplasia
Human monoclonal antibodies as candidate therapeutics against emerging viruses
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 462-470 doi: 10.1007/s11684-017-0596-6
The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges to global public health and highlights the urgent need for novel antiviral approaches. Monoclonal antibodies (mAbs) have been successfully used to treat various diseases, particularly cancer and immunological disorders. Antigen-specific mAbs have been isolated using several different approaches, including hybridoma, transgenic mice, phage display, yeast display, and single B-cell isolation. Consequently, an increasing number of mAbs, which exhibit high potency against emerging viruses in vitro and in animal models of infection, have been developed. In this paper, we summarize historical trends and recent developments in mAb discovery, compare the advantages and disadvantages of various approaches to mAb production, and discuss the potential use of such strategies for the development of antivirals against emerging diseases. We also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola virus and discuss prospects for the development of mAbs as therapeutic agents against emerging viral diseases.
关键词: human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 399-411 doi: 10.1007/s11684-010-0170-y
关键词: hepatocellular carcinoma hepatitis B virus X protein β -catenin cell adhesion E-cadherin transcriptional activation
NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 177-184 doi: 10.1007/s11684-010-0038-1
关键词: nucleoside reverse transcriptase inhibitors human immunodeficiency virus mitochondrial DNA D loop mutation
《医学前沿(英文)》 2022年 第16卷 第4期 页码 584-595 doi: 10.1007/s11684-021-0844-7
关键词: hemophilia A adeno-associated virus (AAV) human/rat hybrid factor VIII gene therapy dual chain strategy
智能手机成像的晶片上基于逆转录环介导等温扩增(RT-LAMP)技术的全血中HIV-1检测 Article
Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir
《工程(英文)》 2015年 第1卷 第3期 页码 324-335 doi: 10.15302/J-ENG-2015072
病毒载量测量对于人类免疫缺陷病毒 (HIV) 阳性患者长期临床护理来说是一个必不可少的工具。然而,考虑到病毒载量测量所需的仪器体积、成本和操作的复杂性,在医疗基础设施较差的偏远地区 (尤其是在被HIV感染人群比例较高的地区) 普及标准的病毒载量测量仪器是较为困难的。为提高该检测方法的普及性,人们已经开始开发可以进行即时检测的病毒载量检测平台,然而尚没有解决办法能够同时满足低成本、便携、易于操作等多种实际要求。本文通过运用微流体和微型硅晶片平台,对经过最低程度处理的含有HIV的全血样本进行了逆转录环介导等温扩增 (RT-LAMP),并利用智能手机进行了荧光检测。集成实验检测结果表明,一滴约60 nL的反应液滴中仅有的3个病毒依然可以通过RT-LAMP技术被检测到,这相当于每微升全血样品中只有670个病毒。该技术在数字化RT-LAMP方法上具有重要意义,扩展该技术能够实现对HIV阳性患者在临床护理中采集指血进行病毒载量检测。研究结果显示,病毒载量检测过程所需的各个步骤,从血滴的准备到RT-LAMP反应的成像,都可以集成为晶片实验并且可以和移动设备兼容。
关键词: 人类免疫缺陷病毒(HIV) 病毒载量 环介导等温扩增 智能手机 即时检测
Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 192-198 doi: 10.1007/s11684-010-0039-0
关键词: human immunodeficiency virus (HIV) acquired immunodeficiency syndrome (AIDS) co-infection intestinal parasites helminthes protozoa China
Removal of virus aerosols by the combination of filtration and UV-C irradiation
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1627-y
● The removal of virus aerosols by filtration and UV-C irradiation was proposed.
关键词: Filtration system UV-C irradiation Virus aerosol Public health COVID-19
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 260-267 doi: 10.15302/J-FASE-2016116
关键词: antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus
标题 作者 时间 类型 操作
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Molecular network-based intervention brings us closer to ending the HIV pandemic
Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang
期刊论文
Natural history of HIV infection in former plasma donors in rural China
Min ZHANG, Hong SHANG, Zhe WANG, Wei-Guo CUI, Qing-Hai HU
期刊论文
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
期刊论文
Universal influenza virus vaccines: what can we learn from the human immune response following exposure
null
期刊论文
Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected
null
期刊论文
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
期刊论文
Dysregulation of β-catenin by hepatitis B virus X protein in HBV-infected human hepatocellular carcinomas
Lei CHEN, Liang HU, Liang LI, Yuan LIU, Qian-Qian TU, Yan-Xin CHANG, He-Xin YAN, Meng-Chao WU, Hong-Yang WANG,
期刊论文
NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients
Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,
期刊论文
correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human
期刊论文
智能手机成像的晶片上基于逆转录环介导等温扩增(RT-LAMP)技术的全血中HIV-1检测
Gregory L. Damhorst,Carlos Duarte-Guevara,Weili Chen,Tanmay Ghonge,Brian T. Cunningham,Rashid Bashir
期刊论文
Co-infection of HIV and parasites in China: Results from an epidemiological survey in rural areas of Fuyang city, Anhui province, China
Li-Guang TIAN MPH, Jia-Xu CHEN PhD, Yu-Chun CAI BM, Jian GUO MPH, Xiao-Mei TONG, Qin LIU DVM, Xiao-Nong ZHOU PhD, Tian-Ping WANG PhD, Xiao-Mei YIN, Wei-Duo WU, Li ZHOU, Feng-Feng WANG, Zhen-Li WANG MSc, Guo-Jin CHENG, Peter STEINMANN PhD, Lan-Hua LI MSc,
期刊论文